CALAN

Do NOT use Calan if:

• you are allergic to any ingredient in Calan
• you have certain heart problems (eg, left ventricular dysfunction, sick sinus syndrome, second- or third-degree heart block and do not have a pacemaker), very low blood pressure, or moderate to severe congestive heart failure (CHF)
• you have atrial fibrillation or flutter and a pre-excitation syndrome (extra conduction pathway in the heart), such as Wolff-Parkinson-White (WPW) syndrome or Lown-Ganong-Levine (LGL) syndrome
• you have shock due to serious heart problems
• you are taking dofetilide, or you have taken disopyramide within the past 48 hours.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Calan. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have heart failure or a recent heart attack with lung congestion, low blood pressure, or heart problems (eg, a very slow heart rate, heart block, heart valve disease)
• if you have kidney or liver problems, muscular dystrophy, or a neuromuscular disease
• if you are taking another blood pressure medicine or you are being treated for cancer.

Some medicines may interact with Calan. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Beta-blockers (eg, propranolol), clonidine, disopyramide, ketolides (eg, telithromycin), macrolides (eg, erythromycin), or ritonavir because they may increase the risk of Calan’s side effects
• Phenobarbital, rifampin, or St. John’s wort because they may decrease Calan’s effectiveness
• Aldosterone blockers (eg, eplerenone), aspirin, carbamazepine, colchicine, cyclosporine, digoxin, dofetilide, doxorubicin, dronedarone, eletriptan, erythromycin, everolimus, flecainide, HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin), lithium, narcotic pain relievers (eg, fentanyl), paclitaxel, quinazolines (eg, terazosin), quinidine, ranolazine, theophyllines, or tolvaptan because the risk of their side effects may be increased by Calan.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Calan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

• • Calan may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Calan with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Calan; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Calan may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Tell your doctor or dentist that you take Calan before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including liver function, kidney function, complete blood cell counts, electrocardiogram (ECG), and blood pressure, may be performed while you use Calan. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Calan with caution in the elderly; they may be more sensitive to its effects.
  • Calan should not be used in childen; safety and effectiveness in children have not been confirmed.
  • Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Calan while you are pregnant. Calan is found in breast milk. If you are or will be breast-feeding while you use Calan, check with your doctor. Discuss any possible risks to your baby.